Endocrine Abstracts

Testicular adrenal rest tumors (TART) are frequently detected in male patients with 21-hydroxylase (21-OH) deficiency. Increase in plasma ACTH levels, due to cortisol deficit, is responsible for TART growth. Indeed, glucocorticoid substitution reduces both plasma ACTH and TART development in the majority of patients. Nevertheless, some patients with TART are resistant to the glucocorticoid treatment, suggesting the existence of other factors stimulating TART growth. The aim of...